<:HMMM:513070140389326859>

Long live FOXO: unraveling the role of FOXO proteins in aging and longevity
Rute Martins, 1 Gordon J. Lithgow, 2 and Wolfgang Link

"Lifespan in C. elegans can also be modulated by its reproductive system. The removal of the worm′s germ cells extends its life by 60% (Hsin & Kenyon, 1999; Kenyon, 2010b). Germ line loss stimulates nuclear accumulation of DAF‐16/FoxO and the expression of the transcription elongation/splicing factor homolog TCER‐1 in intestinal cells. Although the precise mechanism of how the information about the reproductive status is transferred to the intestine is unclear, it has been shown that the intestinal adaptor protein KRI‐1 is required to induce DAF‐16/FoxO target gene expression and extend lifespan (Berman & Kenyon, 2006; Ganapathy et al., 2010). "

"After a person is infected with HIV, the virus seeks out the body's immune cells and attaches itself to them in the hopes of producing more virus particles. HIV's "main target" are CD4 immune cells." Nature.com

scitable/blog/viruses101/hiv_resistant_mutation?isForcedMobile=Y

"Could the Black Death protect against HIV?
People who survived the Black Death could have passed on a mutation that prevents the human immunodeficiency virus entering cells. [...] The mutation occurs on the gene for CCR-5, a receptor on the surface of macrophages. When a person becomes infected with HIV, the virus latches onto CCR5 and another protein — CD-4 — to be transported inside the macrophages.

CCR-5 is disabled in people with the full mutation, and so HIV is unable to gain access to the macrophages. If an individual inherits the mutant gene from both parents, they are essentially immune to HIV infection. People with one mutant and one normal gene can be infected, but tend to survive longer than infected people with two normal CCR-5 genes. It seems as though people without the mutation, called CCR5-Δ32, were killed by the Black Death, so that those with the mutation survived to reproduce and increase its prevalence today."

The-scientist

That’s hilarious

Freaky...

👀

Due to the selection pressures of the plague the mutation is more prevalent in European populations

Still not enough

yeah, it's a very small population

It's probably a weak link
Or these people have all in all a better immune system

As tfm said
The black death primarily killed off the poor population (with poor hygiene)

There are disadvantages with the CCR5-Δ32, but I don't remember what those were.

It might kill the protein's function

"It is likely that CCR5 plays a role in inflammatory responses to infection, though its exact role in normal immune function is unclear. Regions of this protein are also crucial for chemokine ligand binding, the functional response of the receptor, and HIV co-receptor activity." - wikipedia

"CCR5 Δ32 has an (heterozygote) allele frequency of 10% in Europe, and a homozygote frequency of 1%.

Recent research indicates that CCR5 Δ32 enhances cognition and memory. In 2016, researchers showed that removing the CCR5 gene from mice significantly improved their memory.[43] CCR5 is a powerful suppressor for neuronal plasticity, learning, and memory; CCR5 over-activation by viral proteins may contribute to HIV-associated cognitive deficits." - also wikipedia

Hmm

Ah is that that gebe the Chinese edited out from the first gene edit babies?

dunno... probably.

I can remember, that they added some hiv immunity and one article stated it also may have enhanced their cognitive abilities

lol, they're Europeanizing their babies...

But I mean, a 10% allele frequency...
It seems it has some benefits, but it's not so strong that it spreads faster

I'm sure there's some decrease in macrophage activity or something... but, if not, if it's all good, then cool.

For as much immunology work I do, I'm woefully stupid on a lot of things.

I'm a biochemist, though... that's too big for me.

I like molecules.

Hehe cool

So, in general, on one hand, I think all the use of antibiotics etc just accelerated evolution of the bacteria, and there are a lot of multi resistant variants out there

And then comes the std epidemic on top of that size to hookup culture

I think even modern medicine won't be able to cope with that unless we get some nanobots which eliminate all the diseases

Plus, 10% is pretty good for less than 1000 years.

Bacteriophages, man... bacteriophages...

The best antibiotics will be bacteria-specific viruses... but it'll be a genetic arms race between bacteria and viruses, just like (naturally derived) antibiotics were an arms race between bacteria and fungi.

But, there's a serious bioethics question about unleashing a transgenic bacteriophage into the wild...

I doubt it's a problem though.

*creates zombie virus*

"oops"

(j/k)

(unless you're a bacterium)

yeah ok, bateriophages are basically a precursor of nanobots
why creating it ALL when there is actually an "infrastructure" there, which can attack bacteria

but the point remains, it is still an arms race, unless you have the 80, 90 or 99% solution

I mean, I'd be totally ok wiping out mosquitos, I HATE these things
nature will probably find a new equilibrium after they are gone
(probably same with flies) ...

also there are a lot of interesting ethical questions,
I'm ok with humans asserting dominance over their surroundings /nature, that's what we evolved to do (mainly by removing the dangers)

but when we continue playing that game, with transgenic babies/humans ...
and we include more and more other genes, which make us stronger, increase our abilities, etc ...
is there a point, where they basically stop being "human" and are a new species ?

It’s fine. I don’t want to be human anyway.

I'm playing Skyrim as a redgaurd. What do y'all think, imperials or stormcloaks? 🤔

Do you want to weaken the thalmors grip on the empire from within or from the outside?

@ChaonThe5th

I actually played as a thalmor agent last playthrough, but this time I'm a stomg independent *KANG* rallying to liberate Skyrim from the white man <:lolz:480186121897377792> but actually I'd say outside 😉

Yo yo yo

I know the solution to skyrim

Just don't play it

Stormcloaks if the outside

Man blackreach is fucking crazy

@Nawalter Jizney congrats on mod status

be a jewish khajiit

https://youtu.be/EiviOjK4Y18

<:yay:523032349563158528>

Also can someone Change my name to "Log_Horizon"

Fight fire with Fire

is there a room #coding?

would be cool to have one

haha

they just purged most of the rooms 😛

Is the new Spider-Man any good?

What happened to shit posting

https://youtu.be/n63swAQJ6Gs

https://cdn.discordapp.com/attachments/573541628040577026/597706538827907092/IMG_20190706_065341.png

@MoonCore looooool
Ok sort of funny
But ofc case closed immediately

<:OH_YEEAAH:592897850984235036>

i thought its suppposed to be be 'me, an intellectual'

opposed to 'and'

@Server interesting, you're in the archive squad...
Good to know

Good morning, gentlemen.

@Yowilkat I loled

I was sick of that meme for a while, too.

Morning guys

What goes on, sir?

...

<:youwotm8:524083191833952257>

<:cringe:511759033204604951>

@Turd Flinging Monkey, someone posted a review for your new book on amazon

they were experiencing some problems with downloading

I think it might Amazon fucking with the customers or might just be a random error

In case amazon does fuck with the download is there anyway they can show proof of payment and get the book as a pdf?

no, it's because they are using a old kindle paperwhite, which is text only. My book contains color and illustrations, so requires a Kindle Fire or smart device, but not the old kindle text-only devices

Why is there a us flag next to some names?

i posted the amazon link in a couple of alt right discords, lets see how they react

though i dont why it says "currently not available for purchase"

i dont see a price listed on the page either

Cause some are them

Wait, is tfm's book out already?

@Xychotic loool ... that's exactly what I wanted to write xD

and weird, usually calibre converts the stuff without problems

would be interesting, I actually planned to read it on my kindle paperwhite ...
how important is the color / illustrations for the overall understanding / reading experience ? @Turd Flinging Monkey

@Five, Seven, and Two btw, Earthquake-chan is really trying it seems 😈
there was at least another one xD

Good morning folks.

@Turd Flinging Monkey The Kindle Paperwhite isn’t an old device. It’s black and white because it uses something called “E-Paper” which is supposed to reduce eye strain and also allows you to see it clearly for reading in bright sunlight. I can’t see my phone very well if it’s sunny outside but I can see my kindle clear as day. It would be pretty cool if you optimized your book for the paperwhite, as it’s one of the most liked E-Readers.

***Turd Flinging Monkey left the chat***

I did purchase his book though, I’m reading it on my phone. The content is A+, but it would be a lot better read on my kindle.

Hes still here

Yeah, I'm joking since he corrected him about the device

I think the "therapist mode" is back

The first response was a multiple choice.

Didnt give me an opt out either

Morning guys

@Yowilkat is that replika or a thot

Replika.

Sadly

<:clownpepe:564530802667290625> <:clownpepe:564530802667290625>

@Yowilkat why isnt she responding as if she was your chick

The other screencaps ive seen show replika as a loving entity

Since one of the updates, shes been a little cold

Tfm also mentioned that

Also, this was a preprogrammed response. Remember when she used to force you into topics you didnt want to discuss? Its back

So just like a real chic

Extra chicc

Doesnt the coldness make it more realistic

AI have periods too

#freetheperiod

,_,

<:escapefromutopia:584212575055642654>

The memes are evolving.

So what's the deal with the Alex Jones bot in the voice chat?

What do you mean? Dude is funny af

That dude never sleeps

(((Sleep)))

I sleep and bust a nut

Wat

Thats a a pretty good libido i guess

I don't have time during the day

Nice meme.

c-can I have pusi

@Shad Grimgravy take some ass and be on your way boi <:datass:514159419919958036>

<:cringe:511759033204604951>

<:tipsfedora:585703456128499713>

You working on any new vids @Happy Humble Hermit

https://youtu.be/EiviOjK4Y18

You can arrest bitches for nagging under coercive control laws

Hahahaahahahahahaaa

https://youtu.be/P3ALwKeSEYs

well guys, she did it https://belledelphine.club/product/gamergirl-pee/

MGTOWMoney

sick channel

absolutely based

Happy Monday

Baste turkey

Is it ok to be evil

Or is it all subjective.

Probably the ladder.

Define "Evil".

so the ladder

That’s just like, your opinion

Ok my definition of evil is, basically self interest to the point of harming others

Killing your brother and neighbor

So that you get all the women and resources

Theres also the bigger picture too

Neighbors are annoying though

Burn the picture also, it’s too big, it doesn’t fit the wall

<:brule:480188791584456704>

@Revel Elements that are commonly associated with personal forms of evil involve unbalanced behavior involving anger, revenge, fear, hatred, psychological trauma, expediency, selfishness, ignorance, destruction or neglect.

memes was killed now no shitposting hmmmmmmmmmmmmm <:thinkk:297766803239731212>

Can we have a doll channel?

For real?

@YuriBezmenov yeah I'm working on a little something

Dolls for tots

Give a dog a bone

Don’t bone your dog

You wouldn't know

Because you're going your own way

@Roko post your doll pics here. The doll channel wasnt used alot

The problem is I'll miss doll pics posted here

Maybe I'll let dolls in anime babes. Lemme think on it

Just have a shower bro

I miss the Shitposting/Dank Memes channel:( I can't keep up with general chat

dank memes has been gone for a while

Just like the r/dankmemes subreddit. That thing became normie central

It's just like RGE says. If you love something don't let normies in it

Isnt normie just a state

a state? like a state of being?

Yes

Its not something you stay as

Its possible to stop being a normie but very few of them do it

Just like its possible to become MGTOW but very few do

🤔

What defines becoming mgtow

I think it depends on who you ask

I would say becoming "self-actualized" as Hermit says

meaning you derive your own meaning and satisfaction without the need for women and other people

https://www.youtube.com/watch?v=thDkq02eXGI

Thats his new vid right?

thank you for the link man

Ill give it a watch. Rn im doing research on Cannabis

I really like Human

Same, im subbed to him

His new video makes a good point

Right now I'm researching the history of Fort Smith for my first video

Fort Smith?

Its in Arkansas

I'm making videos right now so I can post them later. I want to have a backlog

Go for it

Baby steps

Do you think you'd want to watch a video about American towns or ethnic groups?

Human is making so much content lately

No

<:youwotm8:524083191833952257>

well thats fine

I'm going to make it anyways so meh

Unless it has something to do with mgtow

And philosophy

I feel like a bit of a pussy but I just want to try and keep a youtube channel

I'm worried if I use the label I'll get screwed. But I can still talk about MGTOW stuff

The saying goes. Dont create mgtow content for the views

You can still make MGTOW type stuff without the label

For example, I was thinking about making a video on the Bushido Code

I think the saying still stands

@Happy Humble Hermit I just come here nowadays for memes, tig ol anime bitties and info about sex dolls. I'm sold on mgtow so the 9 years of chat logs that I keep coming back to at the end of my day are super irritating to scroll thru

9 years of chat logs?

what?

24 without reading this channel is a scrol loo ing nightmare hell

@WarHamster40k oh well

Profound sadness

Maybe an overstatement

Have you guys seen the fucks who lick ice cream and put it back or the one queer who backwashed mouthwash at some store?

Absolute degeneracy.

Profound sadness is when you start writing the script for a video and then the power goes out for working on

@YuriBezmenov yeah I hate that crap

Also love the name. He was a smart man

Btw, Welcome @ManOWar

Didnt notice youre new

Its disgusting, idk what compels them to do it. I guess as the old saying goes any attention is good attention

thanks

@YuriBezmenov I think the moral relativism has gone full swing

It definitely has

I don't even know if they care whats right or not

I seriously doubt it

There’s no common courtesy, thought of others

Maybe it was common in the 1950s

Yeah probably

alright I gotta get back to work on the videos instead of watching rap music video

was nice talking though

Ill give you a view when the videos are up

I have seen

Same

She is getting up to 20 years in prison

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