There are a few main issues, with a true Quebec separation for the rest of Canada. The first is the loss of control of the Saint Lawrence, one of the major waterways into the more central portions of Canada. Second is that much of northern Quebec houses power generation facilities like solar farms, hydroelectric dams, and wind turbine fields, almost all of which were payed for and installed by the Canadian government, in order to separate they would be required to hand over a sizable chunk of land to Canada that is supposed to be Quebec, or they would have to pay several times their annual GDP to buy the infrastructure and generating facilities outright. The last issue is that aside from perhaps New Brunswick, most of the maritime provinces are Anglo and would not want to separate from Canada. But this would mean that the 3 or 4 maritime provinces that wanted to remain in Canada would have no land connection to the main body of the country and would have to travel through Quebec or the US in order to get to the capital/90% of the rest of the countries land mass.
