Message from @n0ne0ther
Discord ID: 690238393942147136
is it possible to do a tl;dr on that @ᚠᚢᛖᛚᛖᛞᛒᚣᚳᚨᚿᚳᛖᚱ ?
$0.04/dose in the developing world. If this works out we're going to beat this bitch
Yeah, if we have working therapeutics then this isn't going to be anywhere near as big an issue.
I'm still thinking we will have to come up with a plan to expose everyone we can afford to eventually over the next 12-18 months.
I mean the UKs herd immunity plan isn't a bad idea, I just think not doing a lockdown to start with before we can judge how much of an impact it will have is a bad idea.
Inhibition of nucleic acid synthesis, protein synthesis, and glycolysis; it also binds with hemazoin in parasitized erythrocytes. Is what I can think of right now, but the mechanisms are generally not that well-known even though they are studied.
Hydroxychloroquine? is that what you guys were referring too. Honestly I doubt it to be effective.
Another possibility is an artificial version of the ACE2 receptor that would bind to the virus and then prevent it from mating with live cells:
https://youtu.be/jAW6VBWTiAA
This was apparently developed for the original SARS.
Basically, chloroquine has been used for Influenza and is well-known too inhibit replication of Orthomyxoviridae (Influenza family). Still only a hypothesis in the inhibition of glycosylation of Coronavirus receptor ACE2.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1232869/ from 2005. So basically every single drug that they report as potential has been researched for SARS etc.
TL;DR why not throw everything at it and see if it works.
I think someone said carpet bombing stratergy.
Most of the things they want to try have few or rare side effects.
Or many side effects.
depends.
True, there is some limit to what we should be trying first.
Well I honestly have no problems with it as long as people are properly informed of it being a carpet bombing stratergy.
But something like anti-malaria meds should be incredibly well documented because they are so widely used.
Probably know every possible drug and condition interaction by now.
So we might be starting wide trials of hydroxychloroquine.
It's contraindicated in a lot of the same people that are also high risk for death so it isn't a magic pill to end this in a day
But if we can say use this as a treatment for decent parts of the population we could try letting it burn through as many people as possible fast.
But that's likely to take a few months of trial and follow-up to find out.
boomer remover
Oh boy, I hope that doesn't get broadcast too far and misinterpreted. Preparing yourself for this situation to last 18 months is not the same thing as "buy 18 months worth of shit NOW" but you know how some idiots will hear that statement.
<:swet:671404160393936948>
Spain 🇪🇸
Infected: 17,395
**Deaths: 803**
Serious: 939
Critical: 0
Recovered: 1,107
kekalek
@Monstrous Moonshine reeee
<:Trump_Pepe2:462291833427329035>