your feet toughen up quick

i love the feeling of running a 50k (31 miles)

i never felt more alive

http://www.jbc.org/content/early/2014/08/20/jbc.M114.592576.abstract

https://www.youtube.com/watch?v=oA8qCw8xM54

```Mechanism of Metformin-dependent Inhibition of mTOR and Ras Activity in Pancreatic Cancer: Role of Sp Transcription Factors```

Live

Popping blisters is satisfying, especially if those blisters appear under calluses.

i always pop blisters with a needle

Just get a knife, cut open your callus, I know?

Inhibiting MTOR is pretty certainly the main thing metaformin is doing

its retarded to just walk on them and make them bigger

I'm not saying def don't take it

Just that I'm personally not, yet

I want MTOR to be more active sometimes

I'm pretty good at calorie restricting in actuality under my current regime

And taking Sirts

for me metformin seems to work great

Don't amps increase muscle tone and reaction time?

i am one of those people that puts on muscle by just thinking of lifting things

you don't need to calorie restrict for mtor, just fast

My aunt is on it for diabetes and asked me about wanting to get off it, and I told her to think twice as people seek it out for anti-aging

strangelove what do you think of NSI-189

Def if I was also needing it to control diabetes, I'd take it over other drugs

@TheUserNameofPeace did you learn to stop worrying and love the bomb? I need to know how!

my mom has diabeetus

Idk much about NSI-189

Tell me about it

@Deleted User Embrace the *bomb-almighty*.

why does everyone have diabeetus, just stop eating sugar

NSI-189 completed a phase I clinical trial for MDD in 2011, where it was administered to 41 healthy volunteers.[6] A phase Ib clinical trial for treating MDD in 24 patients started in 2012 and completed in July 2014, with results published in December 2015.[1][7] In July 2017, it was announced that a phase II clinical trial with 220 patients failed to meet its primary effectiveness endpoint in MDD.[8] Upon the announcement, Neuralstem stock plummeted by 61%.[9] More detailed analysis of the trial results was released in December 2017 and January 2018. It revealed statistically significant improvements on patient-reported depression scales and in aspects of cognition for the 40 mg/day dose. Of particular note are improvements in memory (effect size Cohen's d = 1.12, p = 0.002), working memory (d = 0.81, p = 0.020), and executive functioning (d = 0.66, p = 0.048) as measured by the CogScreen computerized test.[

basically studies seem to show NSI-189 has stat sig increases in hippocampal volume

but its not an SSRI

with all the SSRI sides

Sugar is more addictive than crack

just stop eating it

You almost have to be forced off of it

it is addictive

i find it easier to not even start

it is addictive if you don't eat enough calories

once i eat one cookie i just want more