''We use our results to provide a back-of-the-envelope calculation of how much of the
dramatic growth in drug overdose deaths can be accounted for by the introduction and marketing
of OxyContin. On average, the national drug overdose death rate increased by 6.89 deaths per
100,000 since 1996, comparing the mean during the 1996-2017 time period (11.33 deaths per
100,000) relative to the 1991-1995 baseline mean (4.44). The additional exposure to
OxyContin’s launch and marketing for non-triplicate states led to 4.49 more deaths per 100,000,
which is equivalent to 65% (4.49/6.89) of the national growth in overdose death rates since
1996. As an additional benchmarking exercise, we consider the additional deaths that could be
attributed to an increase in initial OxyContin exposure moving from no exposure to the national
level of exposure. To make this calculation, we need to scale our mortality results by the
difference in OxyContin exposure between non-triplicate and triplicate states.66 This
extrapolation suggests that moving from no OxyContin exposure to the national average would
lead to 5.56 more deaths per 100,000, which is 81% of the rise in the overdose death rate since
1996. We note that this extrapolation is far out-of-sample since no part of the United States was
unexposed, so we interpret it with caution. However, these calculations suggest that exposure to
OxyContin may explain a large share of the growth in drug overdose deaths since the mid-1990s. ''
https://cdn.discordapp.com/attachments/373119138689974273/651477636568317962/unknown.png

I read somewhere that opioids effect the ventrolateral and orbitiofrontal prefrontal cortexes.

Something to do with chronic overstimulaton

@Master, remember the Athenians. this is what eplains the opioid crisis specifically overdose death rates

kk

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look at this cringe

@Deleted User are we playing halo?

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fries and onion rings @Sjruruchunchun @Summer~ 🍃

not outloud to eat in here

sdfsdf

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Hey guys

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I love judge dredd

**I FUCKING LOVE IT**

it's like

based

oh yea forgot metaphysicians used to be heavily criticised by hegel and marx for it's stationaryness

Sanrikuza gang UwU

say no to narita!!!

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@Hagar is this you ?