NSI-189 completed a phase I clinical trial for MDD in 2011, where it was administered to 41 healthy volunteers.[6] A phase Ib clinical trial for treating MDD in 24 patients started in 2012 and completed in July 2014, with results published in December 2015.[1][7] In July 2017, it was announced that a phase II clinical trial with 220 patients failed to meet its primary effectiveness endpoint in MDD.[8] Upon the announcement, Neuralstem stock plummeted by 61%.[9] More detailed analysis of the trial results was released in December 2017 and January 2018. It revealed statistically significant improvements on patient-reported depression scales and in aspects of cognition for the 40 mg/day dose. Of particular note are improvements in memory (effect size Cohen's d = 1.12, p = 0.002), working memory (d = 0.81, p = 0.020), and executive functioning (d = 0.66, p = 0.048) as measured by the CogScreen computerized test.[

basically studies seem to show NSI-189 has stat sig increases in hippocampal volume

but its not an SSRI

with all the SSRI sides

Sugar is more addictive than crack

just stop eating it

You almost have to be forced off of it

it is addictive

i find it easier to not even start

it is addictive if you don't eat enough calories

once i eat one cookie i just want more

eat fat

@fuguer I think most memory nootropics work primarily on hippocampus

You lose your desire for it after a week or so off

but that week is hell

Any clue on NSI's MOA?

yeah of course, and hippocampus is the primary source of neurogenesis in adult primates

ya

if you want to stay smart and sharp as youa ge

and not be withered shell of your former self

lmao just be healthy

ever notice most old people like 80 and 90 arent really all there

most of their brain is already dead

yeah

theyre like ghosts just going through the motions

healthy brain won't degenerate

yeah, especially if your doctor puts them on a no cholesterol diet

That's why to do longevity stuff

Esp. brain

Same

yeah no cholesterol and statins will destroy your brain

yup

thats why you eat eggs

all elderly are put on statins

your brain is like 90% cholesterol

cholesterol and choline

gives them dementia

best breakfast possible

who controls the medical industry?

My current regimen is successful in supporting me suppressing appetite and eating wtihin a very narrow window, and also a lowered calorie load

You can be born with diabetes lol