@DarthSammich the 4chan retaking of Detroit was always personal favorite

what is inflammed?

the brain?

its convincing to me tbh

yes

Sad that it never happened

It's the brain buy also more

You're relying on anecdotes. Also, nobody is saying lifestyle changes can't help clinical depression, but depression is something that can occur due to no obviously negative stimuli.

Nervous system has other major centers

yes prescribed montelukast (singulair)

@DarthSammich if have like 10 broham and a couple of dallors

There's no proof that depression can occur without stimuli

nobody is relying on anecdotes, I'm talking about statistical evidence

https://youtu.be/xp4Ob-8_X9Q

being tired correlates with depression

that will fix brain inflammation

this is not a shift in genetics this is a shift in environment

@DarthSammich we could def do it we need alot of MERS dough

I remember reading something about coal miners from a hundred years ago having symptoms that were probably depression

MERS?

basically depression causes you to be kind of slow

depression just causes a permanent negative feeling

depression LITERALLY causes your hippocampus to shrink in size

and a lot of times not hungry, not having energy and feeling numb

it can show up on an MRI

Women aren't as good at handling work/war stresses

@DarthSammich yea there only one place to get food in the D, food would be the hardest thing to get

sadly i get atypical depression its opposite

like a feeling that isn't really a feeling

sleep a lot and eat more

This is why many people who would be considered to be in high standing never tell people about their depression, because they have identifiable reason to be depressed, they assume they're just ingrates.

some kind of numbness in the body

yes

@DarthSammich that and not shot

like its almost impossible to move

it's like a feeling of grief permanently

Sleeping 9 hours is pretty awesome

<:steflol:561214382181318656>

@fuguer yes sometimes the feeling is recurring

@esotericpazuzuism many of those plots on the edge of the city are going back to wild lands. Crops. As far as not getting shot? As long as the whole neighborhood is your group that isnt an issue

what people should do is have fun

actually

throw on a movie with cool action or that makes you laugh

that's not going to help

Depression can occur naturally.

if it is recurring and comes around randomly, it does help

@DarthSammich i mean if were going to do it def need a personal army style thing for the first year

This has been proven. There are proven genetic factors in depression.

@fuguer thanks for the antiinflamation medication recommendation

having fun can make you feel worse because you can't enjoy the fun

other people have a long period of depression

rather than small amounts in intervals

I think a big part of whatever my depression is is inflammatory

@Weaboo Kempeitai some correlation isn't proof

@esotericpazuzuism nah, a neighborhood watch/informal militia would suffice

I have literally been congested every day of every season of the past two years

in that case it is a clear sign of physical exhaustion and emotional grief imo

They nogs only go after easy pickings

Was interesting that modafinil was listed as having anti-inflammation effect

yeah depression can for sure be due to inflammation

@Nerthulas talk to MMW and I about this

What is your diet like nerth?

I fucking hate it I can't breathe

@Nerthulas we've been there

my diet is irregular

I cut out wheat

tho

recently

yeah Nerth, just eat more calories and sleep more

Lol

@DarthSammich true but i like having back up , go full drone and armor cars

cut out all grains

Idk if wheat is your issue

<:JFGOD:439598359628611604>

also your lifestyle might be too Spartan

Montelukast will help

grains are shit

Gluten can cause inflammation

maybe hang out with your friends on the regular

I'll order some

cut out dairy dummie

@Sytze Depression and suicide has been shown to run in families.

you will probably feel better

Coeliacs

And Celiacs

if you just set it as part of your routine

https://www.nature.com/articles/s41419-018-0783-7

@Weaboo Kempeitai that doesn't make it genetic. It can be due to family culture, habits, etc

Montelukast treatment for 4 days protected against cell death with 90% more cell death in the vehicle group compared to the montelukast group 24 h after CIR

@Sytze https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065213/

Here is my recommendation, it may or may not work, eat more fruit/vegetables and less dairy, eat two or three meals a day at regular intervals, exercise for 15-30 minutes at moderate intensity once every two days, spend more time outside and ideally in a wooded area with less air pollution.

Grains, sugar, dairy, soy are the first things to cut when going for anti-inflammation diet

Another amazing drug everyone shoudl take is metformin

Also, consider mold

You can buy metformin for like $0.06/pill

You can add back gradually to see what works for you

Anything you may have spilled on carpet or wood or else the creases in your shower panelling, may have mold growth

Metformin is a diabetic drug though

But yeah, I'm not denying stimuli can play a factor, but there's no reason to reject genetics. Why reject genetics as a possible cause?

I'm still not sure on taking it

It's going to turn off MTOR

You won't be adding muscle

if you're eating soy then there's no hope for you

Or adapting to exercise as well

@TheUserNameofPeace <:oof:399031884312739841>

i added muscle fine on metformin

it mimics calorie restriction effects on longevity

you can use met for bodybuilding

same benefits as intermittent fasting

<:basedmama:396156349676781569>

@Weaboo Kempeitai Okay, I can't say genetics doesn't predispose you to depression, but I don't believe it can be the sole cause

Yeah but it does that by turning off MTOR

TNSTAAFL

There's a price

You dont need MTOR

mtor is good

MTOR is primary building pathway

just eat clean

well i was taking metformin daily when running marathons

no problems at all

with muscle mass or recovery

wash your food before consumption

@Sytze Fair. I mean, I'm not denying that sombody predisposed to depression is guaranteed to get it. Alcoholism runs in many family, so I tend to stay away from booze. Similarly, sombody with depression running in the family would probably be advised to take better care of himself.

obviously everyones genetics is different

I'm not saying you can't recover but I doubt you were positively adapting

And I am saying your recovery will be slower

Even Sinclair, in his interview with Rogan, explained there's a tradeoff

I didnt have that problem

I would run a 50k and run a half the next day

You trade physical performance for longevity

Yeah but you were also on amps, yeah?

no comment

https://anabolictv.com/2018/07/metformin-and-bodybuilding/

And anti-depressants

Yeah

no i wasnt on antidepressants

<:CHAD:396569198404435969>

except NSI-189

So all those performance drugs make a difference

Amps?

Oh amphetamines

Bruh

People on amps power through all kinds of pain

Drugs r bad mkay

That's part of why they were developed

after i got my tonsils out im basically immune to pain

Literal battlefield drug

Amphetamines are totally fine.

I walked ten miles yesterday and I have blisters all over my feet now

30 miles is oofy

drugs are bad I don't even drink alcohol or coffee

Idk if I could do that

your feet toughen up quick

i love the feeling of running a 50k (31 miles)

i never felt more alive

http://www.jbc.org/content/early/2014/08/20/jbc.M114.592576.abstract

https://www.youtube.com/watch?v=oA8qCw8xM54

```Mechanism of Metformin-dependent Inhibition of mTOR and Ras Activity in Pancreatic Cancer: Role of Sp Transcription Factors```

Live

Popping blisters is satisfying, especially if those blisters appear under calluses.

i always pop blisters with a needle

Just get a knife, cut open your callus, I know?

Inhibiting MTOR is pretty certainly the main thing metaformin is doing

its retarded to just walk on them and make them bigger

I'm not saying def don't take it

Just that I'm personally not, yet

I want MTOR to be more active sometimes

I'm pretty good at calorie restricting in actuality under my current regime

And taking Sirts

for me metformin seems to work great

Don't amps increase muscle tone and reaction time?

i am one of those people that puts on muscle by just thinking of lifting things

you don't need to calorie restrict for mtor, just fast

My aunt is on it for diabetes and asked me about wanting to get off it, and I told her to think twice as people seek it out for anti-aging

strangelove what do you think of NSI-189

Def if I was also needing it to control diabetes, I'd take it over other drugs

@TheUserNameofPeace did you learn to stop worrying and love the bomb? I need to know how!

my mom has diabeetus

Idk much about NSI-189

Tell me about it

@Deleted User Embrace the *bomb-almighty*.

why does everyone have diabeetus, just stop eating sugar

NSI-189 completed a phase I clinical trial for MDD in 2011, where it was administered to 41 healthy volunteers.[6] A phase Ib clinical trial for treating MDD in 24 patients started in 2012 and completed in July 2014, with results published in December 2015.[1][7] In July 2017, it was announced that a phase II clinical trial with 220 patients failed to meet its primary effectiveness endpoint in MDD.[8] Upon the announcement, Neuralstem stock plummeted by 61%.[9] More detailed analysis of the trial results was released in December 2017 and January 2018. It revealed statistically significant improvements on patient-reported depression scales and in aspects of cognition for the 40 mg/day dose. Of particular note are improvements in memory (effect size Cohen's d = 1.12, p = 0.002), working memory (d = 0.81, p = 0.020), and executive functioning (d = 0.66, p = 0.048) as measured by the CogScreen computerized test.[

basically studies seem to show NSI-189 has stat sig increases in hippocampal volume

but its not an SSRI

with all the SSRI sides

Sugar is more addictive than crack

just stop eating it

You almost have to be forced off of it

it is addictive

i find it easier to not even start

it is addictive if you don't eat enough calories

once i eat one cookie i just want more

eat fat

@fuguer I think most memory nootropics work primarily on hippocampus

You lose your desire for it after a week or so off

but that week is hell

Any clue on NSI's MOA?

yeah of course, and hippocampus is the primary source of neurogenesis in adult primates

ya

if you want to stay smart and sharp as youa ge

and not be withered shell of your former self

lmao just be healthy

ever notice most old people like 80 and 90 arent really all there

most of their brain is already dead

yeah

theyre like ghosts just going through the motions

healthy brain won't degenerate

yeah, especially if your doctor puts them on a no cholesterol diet

That's why to do longevity stuff

Esp. brain

Same

yeah no cholesterol and statins will destroy your brain

yup

thats why you eat eggs

all elderly are put on statins

your brain is like 90% cholesterol

cholesterol and choline

gives them dementia

best breakfast possible

who controls the medical industry?

My current regimen is successful in supporting me suppressing appetite and eating wtihin a very narrow window, and also a lowered calorie load

You can be born with diabetes lol

I've been eating within around 1hour /day

if you're born with diabetes your parents fucked up

Without temptation for the past 5 days

New practices

do you pig out that hour

No

I've eaten less on the whole

It's a hereditary disease, not a neonatal reaction to the mother's diet lol

Except when I bought taffy

never buy taffy

I bought it for trick or treaters

And wound up eating it all

diabetes is due to eating too many carbs lol

lol

https://en.m.wikipedia.org/wiki/Type_1_diabetes @Sytze

I only eat once a day, it works well
Hit macros, don't really worry about calories

i like to go running in nature like this

It's a hereditary disease that inhibits natural insulin production

Not environmental lol

Ya

Me too

nature runs

People say amps wrecked Land but I don't see it tbh. He's just as jittery and awkward as he was when he was on drugs.

Trail running is primal

It says the cause is unknown

We were running through the woods like that for thousands of years